Repair of oral mucosal defects with cryopreserved human amniotic membrane grafts: prospective clinical study

I.B. Kar, A.K. Singh, P.C. Mohapatra, P.K. Mohanty, S. Misra

30 November 2014

 International Journal of Oral & Maxillofacial Surgery  

Abstract

The aim of this study was to evaluate the clinical outcome of the surgical repair of oral mucosal defects using cryopreserved human amniotic membrane (HAM) as a graft material. Thirty-four patients with precancerous lesions such as leukoplakia, erythroplakia, and verrucous hyperplasia were included. Fresh amniotic membrane was obtained from women undergoing elective cesarean section; the membrane was cleaned, prepared in antibiotic solutions, and preserved at -80 °C. Results suggested that HAM promotes healing and epithelialization without specific complications. Thus we conclude that the use of HAM gives promising results in the repair of post-surgical oral mucosal defects.