Spinal duraplasty with two novel substitutes restored locomotor function after acute laceration spinal cord injury in rats

Hongsheng Liang, Changyu Li, Aili Gao, Peng Liang, Yongxiang Shao, Tie Lin, Xiangtong Zhang

20 May 2015

WILEY PERIODICALS, 2012

A dural tear is a common complication after acute laceration spinal cord injury (ALSCI). An unrepaired dural tear is associated with poor locomotor functional recovery. Spinal duraplasty with biomaterials may promote functional recovery in ALSCI. However, an ideal dural substitute has not yet been found. In this work, we investigated the possibility of using a denuded human amniotic membrane (DHAM) or DHAM seeded on bone marrow stromal cells (DHAM–BMSCs) as duraplasty biomaterials