To report the early and late results of patients treated with an aortic homograft for complex aortic native and prosthetic valve endocarditis. The results of the EURECAH registry show that the use of an aortic homograft for native and prosthetic aortic valve and root endocarditis is safe and provides satisfactory early and late survival despite the complexity of the condition, with good long-term durability and low rates of recurrent endocarditis.